|Generic Name||:||Paracetamol BP + Tramadol HCl BP|
|Therapeutic Class||:||Multi-modal Analgesic Combination|
Tramadol is a centrally acting synthetic opioid. It is a pure non-selective agonist of the μ, Δ and κ opioid receptors with higher affinity for the µ receptors. Unlike morphine, a broad range of analgesic doses of Tramadol has no respiratory depression effect. Tramadol has been shown to inhibit re-uptake of norepinephrine & serotonin in vitro, as have some other opioids analgesics. These mechanisms may contribute independent to the overall analgesic profile of tramadol. Paracetamol is non-opiate and non-salicylate analgesic with marked anti-pyretic property. The precise mechanism of the analgesic properties of paracetamol is unknown and may involve central and pheripheral mechanisms.