|Generic Name||:||Itraconazole INN|
|Therapeutic Class||:||Systemic Anti-fungal|
Iconal (Itraconazole) is an orally active triazole antifungal drug that has demonstrated a broad spectrum of
activity and favorable pharmacokinetic profile. Itraconazole inhibits Cytochrome P-450 dependent enzymes resulting in impairment of the biosynthesis of ergosterol, a major component of the cell membrane of yeast and fungal cells. Being integral to the proper functioning of the cell membrane, inhibition of the synthesis of ergosterol leads to a cascade of abnormalities in permeability, membrane bound enzyme activity and co-ordination of chitin synthesis leading to inhibition of growth, abnormal cell wall formation and accumulation of intracellular lipids and membranous vesicles.
Iconal (Itraconazole) capsule is used for the treatment of Oropharyngeal candidiasis, Vulvovaginal
candidiasis, Pityriasis versicolor, Tinea pedis, Tinea cruris, Tinea corporis, Tinea manuum, Onychomycosis, Histoplasmosis. It is indicated in the treatment of systemic candidiasis, aspergillosis and cryptococoosis (including cryptococcal meningitis). It is also used for maintenance therapy in AIDS patients to prevent relapse of underlying fungal infections and in the prevention of fungal infection during prolonged neutropenia.