Levofloxacin is a fluoroquinolone antimicrobial agent that shows antibacterial activity by inhibiting the synthesis of the enzymes topoisomerase II (DNA Gyrase) and topoisomerase IV required for DNA replication, transcription, repairing and recombination. Levofloxacin has wide spectrum of activities against different types of Gram-positive bacteria e.g., Corynebacterium species, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, other species of Streptococci and Gram-negative
bacteria e.g., Pseudomonas aeruginosa, Acinetobacter lwoffii, Haemophilus influenzae & Serratia marcescens.