ANTEPSIN is the brand name of Sucralfate, a basic Aluminium salt of Sucrose octasulphate. Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers. Sucralfate is also used for the treatment of gastroesophageal reflux disease (GERD)[2] and stress ulcers.

Sucralfate is a locally actingdrug. Sucralfate reacts with acid is converted into a sticky gel like substance (Sucralfate polyanion) at the site of ulcer and provides a proactive barrier against acid and pepsin of the stomach. Unlike the other classes of medications used for treatment of peptic ulcers, sucralfate binds to the mucosa,  creating a physical barrier that impairs diffusion of hydrochloric acid in the gastrointestinal tract and prevents degradation of mucus by acid. It also stimulates bicarbonate output and acts like an acid buffer with cytoprotective properties. Sucralfate was approved by the U.S. Food and Drug Administration (FDA) in 1981.