Oxymetazoline HCl is an imidazoline derivative sympathomimetic amine. It is a direct agonist at alpha-adrenoceptors but has no actions on beta-adrenoceptors. It is used as a topical agent on the nasal mucosa, produces a rapid and long-acting vasoconstriction of the arterioles, thus reducing blood flow and diminishing swelling of the mucosa. This results in improved potency of the airway and better drainage of nasal sinuses.